DOE-Based Stability Indicating RP-HPLC Method for Determination of Lacidipine in Niosomal Gel in Rat: Pharmacokinetic Determination
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DOE-Based Stability Indicating RP-HPLC Method for Determination of Lacidipine in Niosomal Gel in Rat: Pharmacokinetic Determination
Lacidipine (LAC) is a calcium channel blocker used in treatment of hypertension. In this study high performance liquid chromatography method (HPLC) is applied to the determination of LAC in rat plasma. The design of experiment used 3factor 3level Box Behnken Design for optimization of mobile phase condition. The effluent was monitored by UV detector at 240 nm, at a flow rate of 1.0 mL/min using...
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متن کاملDevelopment and validation of a fast, simple and specific stability indicating RP-HPLC method for determination of Dexpanthenol in eye gel formulation.
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2014
ISSN: 2153-2435
DOI: 10.4172/2153-2435.1000314